你将学到什么
How to apply the scientific method to pursue research questions.
How to analyze protein purification schemes.
How scientists determine the structure of a protein.
How structure, allostery, and the Bohr effect influence hemoglobin function.
How to interpret graphs, plot behaviors, and calculate constants related to enzyme function.
How pumps, transporters, and channels differ to regulate molecule transfer across membranes.
How G proteins play a key role in signaling.
课程概况
Do you want to prepare for medical school, study a STEM field, become a research scientist, or transition to a career in the booming biotechnology industry? Or maybe you just want to understand the chemical reactions that govern life itself. Join Professor Yaffe, an MIT professor and practicing surgeon, as he guides you through the science that inspires countless doctors, researchers, and students alike.
We developed 7.05x Biochemistry with an emphasis on:
Developing your scientific thinking skills including articulating hypotheses, performing thought experiments, interpreting data, and designing experiments.
Using data based on real scientific experiments and highlighting the scientific process.
Asserting that biology is an active field that changes daily through examples of MIT (and other current) research, not static information in a textbook.
Visualizing real molecular structures with PyMOL to better understand function and mechanism.
Appreciating the quantitative aspects of biochemistry and practicing this quantitation with MATLAB.
Translating topics in biochemistry to diseases and medicine.
Conveying the authentic MIT firehose experience.
Implementing the science of learning in the course design.
We offer a thorough and robust means of certifying edX learners in their mastery of the MITx biochemistry content, through the MITx 7.05x Biochemistry Competency Exam. This challenging option is available only to those who register for the verified-certificate track, and successful completion of this exam is the majority of the assessment grade that counts toward a certificate. The Competency Exam will be open from June 23, 2020 to June 30, 2020.
课程大纲
The course includes the following learning sequences:
Introduction to Biochemistry; pH and Buffers
Amino Acids and Proteins
Protein Purification
Protein Structure
Protein Folding
Hemoglobin and Allostery
Hemoglobin and the Bohr Effect
Enzyme Chemistry
Enzyme as Catalysts
Enzyme Kinetics
Membranes, Channels, Transporters, and Pumps
Blood Clotting
Signal Transduction
预备知识
Undergraduate introductory biology (biochemistry and molecular biology);
Undergraduate introductory chemistry;
Undergraduate organic chemistry I (chemical structures and biological mechanisms)
